Zimmerman HJ, Maddrey WC 'Acetaminophen (paracetamol) hepatotoxicity with regular intake of alcohol: analysis of instances of therapeutic misadventure.' Hepatology 22 Nelson EB, Temple AR 'Acetaminophen hepatotoxicity, fasting, and ethanol.' JAMA 274 Whitcomb DC, Block GD 'Association of acetaminopphen hepatotoxicity with fasting and ethanol use.' JAMA 272īonkovsky HL 'Acetaminophen hepatotoxicity, fasting, and ethanol.' JAMA 274 Tylenol (acetaminophen).' McNeil Pharmaceutical Prescott LF, Critchley JA 'Drug interactions affecting analgesic toxicity.' Am J Med 75 Kartsonis A, Reddy KR, Schiff ER 'Alcohol, acetaminophen, and hepatic necrosis.' Ann Intern Med 105 McClain CJ, Kromhout JP, Peterson FJ, Holtzman JL 'Potentiation of acetaminophen hepatotoxicity by alcohol.' JAMA 244 Seeff LB, Cuccherini BA, Zimmerman HJ, Adler E, Benjamin SB 'Acetaminophen hepatotoxicity in alcoholics.' Ann Intern Med 104 O'Dell JR, Zetterman RK, Burnett DA 'Centrilobular hepatic fibrosis following acetaminophen-induced hepatic necrosis in an alcoholic.' JAMA 255 Kaysen GA, Pond SM, Roper MH, Menke DJ, Marrama MA 'Combined hepatic and renal injury in alcoholics during therapeutic use of acetaminophen.' Arch Intern Med 145 They should also be advised to seek medical attention if they experience signs and symptoms of liver injury such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, and jaundice. Patients should be warned not to exceed the maximum recommended total daily dosage of acetaminophen (4 g/day in adults and children 12 years of age or older), and to read all prescription and over-the-counter medication labels to ensure they are not taking multiple acetaminophen-containing products, or check with a healthcare professional if they are unsure. In general, patients should avoid drinking alcohol while taking acetaminophen-containing medications. Therapy with acetaminophen should be administered cautiously, if at all, in patients who consume three or more alcoholic drinks a day. Severe liver injury, including cases of acute liver failure resulting in liver transplant and death, has been reported in patients using acetaminophen. Major Potential Hazard, High plausibility.Ĭhronic alcohol abusers may be at increased risk of hepatotoxicity during treatment with acetaminophen (APAP). Major Acetaminophen (applies to Fioricet) alcoholism

Fioricet dosage